The problem with Dreft for some people has to do with the dyes in it (I believe it is blue dye in the liquid formula but I cannot remember). Some people with sensitive skin need to avoid dyes and fragrance. Even though Dreft is formulated for baby clothes, there are still some people that may not be able to handle some of the chemicals in it. Also, there can be a difference in formulas, whether a powder versus a liquid and the pH of the formulas vary. Liquids require chemicals to keep the active ingredients in suspension so they do not separate. These ingredients depending on the washer, load size, and pH of water may not necessarily rinse out thereby causing skin irritations if there is build up on the clothes. Powders do not need to be kept in suspension so even though one person may not react to the powder version of a brand, they may react to the liquid formula of the same brand. I'm not saying Dreft is bad in general but for people with skin sensitivities, there could be some drying/skin sensitivities based on active ingredient/pH/or additives. I have sensitive skin and use all natural/fragrance free powders for all my clothes and have found through trial and error which brands work for me.